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A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(The British Pharmacological Society, 2009)
AIMS
Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim
was to develop an integrated population pharmacokinetic/pharmacogenetic model and
investigate the impact of genetic variations, ...
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
(Wiley-Blackwell, 2009)
AIMS
Efavirenz exhibits pharmacokinetic variability causing varied clinical response. The aim
was to develop an integrated population pharmacokinetic/pharmacogenetic model and
investigate the impact of genetic variations, ...
Millennium development goals: challenges for health research and care
(2008-09)
This is a book of abstracts of the fourth annual scientific conference organised by the College of Health Sciences, Makerere University on "Millennium Development Goals: challenges for health research and care" at Hotel ...
Campylobacter spp among Children with acute diarrhea attending Mulago hospital in Kampala - Uganda
(2002-05)
Introduction HIV positive (HIV+) women are more susceptible to malaria infection during pregnancy than their HIV negative (HIV-) counterparts but the actual prevalence of infection in Ugandan pregnant women is not known. ...
Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia
(The American Society of Tropical Medicine and Hygiene, 2001)
A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short term ...
Comparison of transformation frequencies of commonly drug resistant and suceptible serotypes of streptococcus pneumoniae.
(2009-09)
Streptococcus pneumonia (pneumonococcus) is a leading human respiratory pathogen that causes a variety of serious mucosal and invasive diseases. There are atleast 90 serotypes of pneumonococcus but it has long been observed ...
Programmed cell death in neurodegenerative brain disease
(2008)
Death of brain cells by either apoptosis or necrosis is the hall mark of the pathology of most brain infections such as Alzheimer’s disease and AIDS dementia. The death of astrocytes in association with brain tumours appears ...
Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude
(Elsevier, 2007)
The α- and β-tubulin genes from Onchocerca volvulus were individually expressed for the first time in Escherichia coli (DH5α). The recombinant tubulins were purified, renatured and reconstituted into oligomers, probably ...
Characterization of penicillin intermediate serotypes of streptococcus pneumoniae carried by human immunodeficiency virus-infected adults and healthy children in Uganda
(Mary Ann Liebert, Inc., 2007)
There are little data on the genetic relatedness between antibiotic-resistant pneumococcal isolates colonizing the Ugandan population. Penicillin-intermediate pneumococci of serogroups or serotypes rarely or not previously ...
Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria
(Lippincott Wilkins & Williams, 2008)
Background: Inpatient treatment for malaria without microscopic confirmation of the diagnosis occurs commonly in sub-Saharan Africa. Differences in mortality in children who are tested by microscopy for Plasmodium falciparum ...