School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 101-120 of 397
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Effect of vitamin d binding protein gene polymorphisms and vitamin d bioavailability on cathelicidin expression in tuberculosis infection and disease
(Makerere University, 2023-01)Background: The human antimicrobial peptide cathelicidin (LL-37) is involved in host innate immunity by the after activation of Toll-like receptors (TLRs), resulting in direct killing of Mycobacterium tuberculosis (MTB). ... -
Activity and dermal safety of Citrus limon (L.) Burm. f oil from Soroti, Uganda against selected Gram positive and Gram-negative bacteria.
(Makerere University, 2018-08-02)Background: Essential oils are widely used for culinary and nonculinary purposes like nutraceuticals, traditional medicine, aromatherapy and cosmetics. Genus citrus of the Rutaceae family has several plants including Citrus ... -
Pharmacokinetic/pharmacodynamic Modeling to optimize efavirenz dosing in HIV/AIDs infected children from Sub-Saharan Africa.
(Makerere University, 2022-12)Aim:Using a model‐based approach, the efavirenz steady‐state pharmacokinetics in Sub-Saharan African children is characterized, quantifying demographic and genotypic effects on the drug's disposition. Simulations are also ... -
Development and validation of an HPLC-UV method for the simultaneous determination of Efavirenz and Dolutegravir in human plasma
(Makerere University, 2022-12)Background: Although HIV/AIDS possess a challenge, global efforts have been mounted to address the epidemic. These include the massive role out of anti-retroviral therapy (ART) globally. To date either efavirenz or ... -
Perspectives of patients with advanced cancer on information disclosure during the informed consent process for clinical care at the Uganda Cancer Institute
(Makerere University, 2022-01)Informed consent is a widely accepted legal, ethical and regulatory requirement in medical care and research, but its practice varies by context and the reality often differs from the theoretical ideals. Disclosure of ... -
Assessment of quality of raw bovine milk sold in Kampala City: A cross sectional study
(Makerere University, 2021-03)Background: Recently there has been increasing reports concerning the safety of certain foods consumed in Uganda. Milk and meat sold on the Ugandan market have been reported to be contaminated with chemicals or adulterants ... -
B cell responses, immune modulation, and survival among patients with HIV-associated cryptococcal meningitis.
(Makerere University, 2023-01-17)ABSTRACT Introduction: A clear mechanism to advance treatment that would improve survival after HIV-associated cryptococcal meningitis despite antifungal therapy in sub-Saharan Africa remains elusive. We hypothesized ... -
Characterisation of pelvic types, inlet and outlet views using computed tomography in the Ugandan population
(Makerere University, 2022-07)Introduction Radiographic assessment of the pelvis requires AP, inlet and outlet views. The pelvic inlet and outlet views have traditionally been done at 45o cranially and caudally respectively. While these views have ... -
Genomic characterization of SARS-CoV-2 from Uganda using MinION Nanopore sequencing
(Makerere University, 2022-12)Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus with a single-stranded, positive-sense RNA genome of approx. 29.9 kilobase pairs. The genome undergoes genetic mutations ... -
Exploring the global genetic diversity of P. falciparum Pf113 malaria vaccine candidate gene
(Makerere University, 2022)The malaria disease burden is still of great concern especially in sub-Saharan Africa among children below the age of 5 years. Evolution of the P. falciparum parasite in response to intervention measures as well as the ... -
HIV-1 co-receptor usage of contemporary transmitted/ founder viruses in Uganda
(Makerere University, 2022-12-21)Background: Globally, HIV remains a global public health threat despite the serious efforts to stop it using combination antiretroviral therapy. This could be attributed to the lack of preventative and curative treatment ... -
Comparison of the performance of RNA extraction kits used in the diagnosis of COVID-19 against TRIZOL-the gold standard for RNA extraction
(Makerere University, 2022-12)Background: During the COVID-19 pandemic, the Test-Trace-Isolate-Quarantine (TTIQ) strategy was used to break chains of transmission. Diagnosis is a key step in this strategy, and it is done using various RNA extraction ... -
Patient single nucleotide polymorphisms assiocated with Mycobacterium tuberculosis genotypes in Ugandan population
(Makerere University, 2022-12)Uganda is one of the 30 World Health Organization-designated countries with a high burden of TB/HIV, with three main dominant genotypes that cause tuberculosis. Recent studies have shown that the M. tuberculosis Uganda ... -
Extended automated NGS pipeline for reproducible analysis of mosquito genomes
(Makerere University, 2022-11)Over the past decade, the decreasing costs of sequencing have facilitated the agnostic interrogation of vector genomes, giving access to an ever-expanding volume of high quality genomic and transcriptomic data. Today, the ... -
Effect of hydrocortisone hormone on in-vitro reactivation of HIV-1 reservoirs
(Makerere University, 2022-07)The persistence of the HIV-1 reservoir in infected individuals represents a major hurdle to the development of a cure and complete eradication of HIV-1 infection. Stress hormones have also been shown to modulate immune ... -
Development of an in- house IgM and IgG ELISA for detection of exposure to SARS-COV2
(Makerere University, 2022-12)Background: Coronavirus disease of 2019 (COVID-19), proved a fatal respiratory disease and affected millions globally. Due to the faster transmission nature of the virus and any other predicted forms of viral mutations, ... -
Correlation of plasma HIV-1 p24 antigen levels with viral load in samples of HIV positive patients on ART in Uganda
(Makerere University, 2022-12)Globally, a total of 38.0 million people living with HIV, of which 1.7 million people became newly infected with HIV in 2019. Additionally, an average of 690,000 people died from AIDS-related illnesses in 2019, and 26 ... -
Evaluation of pre-existing cross reactive cellular immune responses to SARS-CoV-2 in Uganda
(Makerere University, 2022-12)Background: A low severity of COVID-19 disease has been reported in the Africa population more so in Uganda as compared to other regions like Europe, America and West Pacific. Over 169,996 people have been infected with ... -
Insights into genomic variations between Mycobacterium tuberculosis compartmentalized in the lungs and blood of HIV-infected individuals in Uganda
(Makerere University, 2022-08-19)Introduction: Mycobacterium tuberculosis (MTB), particularly clinical strains present a genomic diversity that ranges from several single nucleotide polymorphisms (SNPs) to insertions and deletions (INDELS). This study ... -
Morphometric variations of the pterion among skulls at the Galloway Osteological Collection in the Department of Human Anatomy Makerere University
(Makerere University, 2022-12-15)Background: The pterion is an important anatomical land mark in neuro surgery, it’s also important in Forensic examination of the human skull, to anatomists when teaching undergraduate medical students and postgraduates ...