School of Bio-Medical Sciences (Bio-Medical) Collections
Recent Submissions
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Cytokine profiles of HIV-associated COPD in a Ugandan Cohort
(Makerere University, 2024-11-18)Introduction:COPD is a chronic lung condition characterized by irreversible airflow obstruction and encompasses chronic bronchiolitis and emphysema. Cigarette smoking is the predisposing factor in over 50% of cases but ... -
Development of an antigen agglutination test for rapid screening of COVID-19 in low laboratory capacity and field settings
(MAKERERE UNIVERSITY, 2024-11-29)The transition of COVID-19 from a pandemic to a general disease has highlighted the need for affordable and accessible diagnostic tests to control the spread of SARS-CoV-2. While PCR tests have been the gold standard for ... -
Whole-Genome Sequencing-based characterization of staphylococcus aureus in hospital settings within East Africa
(Makerere University, 2024-12-06)Background: Staphylococus aureus, a Gram-positive facultative anaerobic bacterium, is a prominent pathogen responsible for a wide range of infections, from minor skin conditions to severe, life- threatening diseases. ... -
Performance evaluation of Sanity 2.0 system in detecting high risk Human papillomavirus in Uganda
(Makerere University, 2024)Aim: We aimed to evaluate the performance of the Sanity 2.0 system as a point-of-care screening test for high-risk Human papillomavirus (hr-HPV) using Cobas 4800 as the gold standard. Background: Cervical cancer is a ... -
Bacteremia in hematologic cancer patients with febrile neutropenia in Uganda
(Makerere University, 2024)Background There were 19.3 million new cancer cases and 10 million cancer deaths which occurred in 2020. Compared to high-income countries cancer is a growing public health problem in sub-Saharan Africa, where mortality ... -
Evaluation of the Liofilchem rapid ESBL NP test for the detection of extended spectrum beta-lactamases in Enterobacteriacea in complicated urinary tract infections at Mulago Hospital using direct urine samples
(Makerere University, 2024)Introduction: There is a growing burden of UTIs complicated by drug resistant microorganisms. Antimicrobial resistance (AMR) is a growing global public health threat, with extended- spectrum beta-lactamase (ESBL) producing ... -
Model-based prediction of Dolutegravir dose requirement for HIV exposed neonates in Uganda
(Makerere University, 2024)Introduction: Mother-to-child transmission of HIV is the primary source of HIV infections in children, especially in low-income countries accounting for 14% of all new infections in Uganda. It is recommended that HIV-exposed ... -
Microbial environmental contamination and infection prevention and control practices in the maternity ward of Buwenge General Hospital
(Makerere University, 2024)A 2017 review found that 42.6% of African countries lacked adequate antimicrobial resistance data, with widespread resistance among clinical isolates. In Uganda, despite IPC guidelines, healthcare workers often lack ... -
Evaluation of anticonvulsant activity of the aqueous and total crude extracts of Vernonia amygdalina Delile in pentylenetetrazole-induced seizures in wistar albino rats
(Makerere University, 2024-11-07)Introduction: Seizures due to abnormal electrical activity in the brain leading to convulsions and hence epilepsy have continued to be a serious problem among the population globally including in Uganda. Medicinal plants ... -
Microbiome-induced immune resistance to mycobacterium tuberculosis at the Airway Mucosa
(Makerere University, 2024)Rationale: Mycobacterium tuberculosis (M.tb) remains one of the deadliest infectious pathogens globally. Amidst efforts to control the disease, challenges such as long treatment duration, drug toxicity, and resistance ... -
A comparison of Ubiquitin E3 ligases as surrogate markers for T cell Anergy in active TB
(2024-10-24)Background: Globally, there is an estimated 1.2 million TB-related deaths among HIV-negative people with active TB. Previous studies using ex-vivo and animal models indicate that CD4+ T cell unresponsiveness to Mtb, which ... -
Health profession students' awareness and perspectives on patients' rights
(Makerere University, 2024)Introduction: The concept of human rights in patient care refers to the theoretical and practical application of general human rights. It is universally acknowledged that all human beings possess individual and social ... -
Deciphering Rifampicin resistance among Tuberculosis patients who have trace and indeterminate results on Xpert MTB/RIF ultra assay
(Makerere University, 2024-10-22)Although WHO endorsed the GeneXpert test as the first initial test for Tuberculosis diagnosis, some of the GeneXpert Ultra results include MTB detected trace, RIF resistance indeterminate which necessitates a sample rerun, ... -
Evidence of molecular adaptive evolution of SARS-CoV-2 in Uganda using whole genome sequences
(Makerere University, 2024-10)Background: Seasonal influenza and coronaviruses both exhibit continual adaptive evolution during endemic circulation in the human population. The rapid evolution of human pathogenic RNA viruses can undermine the efforts ... -
Selected bacterial etiology of acute diarrhea in under five children at Mulago National Referral Hospital Kampala, Uganda.
(Makerere University, 2024-10)Background: Diarrhea is understood as the passing of three or more passages of loose or watery stools per day according to WHO and is considered among the major causes of childhood mortality and morbidity. Diarrhea kills ... -
Prevalence, associated risk factors, and consequences of medication errors in poultry practice in Wakiso district
(Makerere University, 2024)Medication errors are a serious health challenge in both humans and animals including in poultry practice in Uganda. However, limited information exists on the extent of burden of medication errors, risk factors and its ... -
Understanding genetic diversity and rapid drug resistance prediction in mycobacterium tuberculosis from whole-genome sequence and other epidemiological data
(Makerere University, 2024-06)Tuberculosis (TB) remains one of the major global health problems with an estimated 1.6 million deaths worldwide. The availability of whole-genome sequence (WGS) data offers a good avenue for understanding genetic diversity ... -
Antinociceptive activity and acute toxicity profile of Leucus calostachys olive in animal models
(Makerere university, 2024-11)Pain remains a cardinal sign and symptom for most diseases and a major reason for patients visiting healthcare providers. Conventional treatment modalities do not adequately address pain, and as a result, most local ... -
Evaluation of hypoglycemic activity, phytochemical composition and acute toxicity of Opuntia humifusa Raf. cladode extracts in Wistar albino rats
(Makerere University, 2024-10-29)Background Local communities in Central Uganda are using the cladodes of Opuntia humifusa in the treatment of diabetes mellitus with the claim that the plant is effective. However, efficacy and safety of the plant is not ... -
Performance evaluation of truenat test for detection of pulmonary tuberculosis among HIV symptomatic patients at Lira Regional Referral Hospital
(Makerere University, 2024)Background: About a quarter of the world’s population has been infected with Mycobacterium tuberculosis, in immune compromised people like in HIV- infected persons, the risk of developing tuberculosis is 22 times higher. ...
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