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Increased prevalence of pregnancy and comparative risk of program attrition among individuals starting HIV treatment in East Africa
(PLoS ONE, 2018)Background The World Health Organization now recommends initiating all pregnant women on life-long antiretroviral therapy (ART), yet there is limited information about the characteristics and program outcomes of pregnant ... -
Midwives’ perceptions towards the Ministry of Health guidelines for the provision of immediate postpartum care in rural health facilities in Uganda
(BMC, 2023)Background Guidelines for clinical practice have been part of the Ministry of Health’s efforts to improve the quality of care for over two decades. Their benefits have been documented in Uganda. However, having practice ... -
Readiness of rural health facilities to provide immediate postpartum care in Uganda
(BMC, 2023)Background Nearly 60% of maternal and 45% of newborn deaths occur within 24 h after delivery. Immediate postpartum monitoring could avert death from preventable causes including postpartum hemorrhage, and eclampsia among ... -
Cryptococcal disease in the era of “test and treat”: Is there cause for concern?
(Oxford University Press, 2017)Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution ... -
Delayed sputum culture conversion in tuberculosis human immunodeficiency virus–coinfected patients with low isoniazid and rifampicin concentrations
(Oxford Academic, 2018)Background. The relationship between concentrations of antituberculosis drugs, sputum culture conversion, and treatment outcome remains unclear. We sought to determine the association between antituberculosis drug ... -
Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome
(Oxford University Press, 2015)Background. Human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is characterized by high fungal burden and limited leukocyte trafficking to cerebrospinal fluid (CSF). The immunopathogenesis of CMimmune ... -
Correlation between co-therapy of efavirenz-based ART and pregnancy among HIV-positive women on hormonal contraceptive implants at TASO Tororo-Uganda: A retrospective review
(2018)Background: We examined the association between EFV and non-EFV based ART regimens and pregnancy outcomes among women who were on HCI in a peri-urban HIV clinic in Tororo, Uganda. Methods: We reviewed and extracted routinely ... -
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
(BioMed Central, 2018)HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although ... -
Prevalence of lipodystrophy and metabolic abnormalities in HIV-infected African children after 3 years on first-line antiretroviral therapy
(Lippincott, 2015)Background: Most pediatric lipodystrophy data come from high-income/ middle-income countries, but most HIV-infected children live in sub-Saharan Africa, where lipodystrophy studies have predominantly investigated stavudine-based ... -
Impaired renal function and associated risk factors in newly diagnosed HIV-infected adults in Gulu Hospital, Northern Uganda
(BioMed Central, 2015)Background: Screening for renal diseases should be performed at the time of diagnosis of human immunodeficiency virus (HIV) infection. Despite the high prevalence of HIV/AIDS in Northern Uganda, little is known about the ... -
Feasibility of conducting a pilot randomized control trial of a psycho-education intervention in patients with a first episode psychosis in Uganda—A study protocol
(PLoS ONE, 2022)Background. Psychotic disorders contribute to significant morbidity and mortality partly due to the chronicity of the illness and high relapse rates. Delivering psycho-education messages about disease etiology, their signs ... -
Gastrointestinal cryptococcoma – Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?
(Elsevier, 2015)The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present ... -
Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda
(BioMed Central Infectious Diseases, 2015)Background: Sputum smear microscopy for tuberculosis (TB) diagnosis lacks sensitivity in HIV-infected symptomatic patients and increases the likelihood that mycobacterial infections particularly disseminated TB will be ... -
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi Sarcoma in Kenya: A cost-effectiveness analysis
(Elsevier, 2022)Background The most effective treatment for advanced AIDS-associated Kaposi sarcoma is paclitaxel or pegylated liposomal doxorubicin (PLD); neither is routinely used in sub-Saharan Africa due to limited availability and ... -
Midwives’ perspectives about using individualized care plans in the provision of immediate postpartum care in Uganda; an exploratory qualitative study
(BMC, 2023)Introduction Individualized care planning has been slowly integrated into practice in Uganda with minimal documentation of how the concept is applied in providing care. This study explored the perceptions of midwives about ... -
Telling the story of intersectional stigma in HIV-associated Kaposi’s sarcoma in Western Kenya: A convergent mixed-methods approach
(Wiley Online Library, 2022)Introduction: The experience of stigma can be multifaceted for people with HIV and cancer. Kaposi’s sarcoma (KS), one of the most common HIV-associated cancers in sub-Saharan Africa, often presents with visible skin lesions ... -
Barriers and facilitators to chemotherapy initiation and adherence for patients with HIV-associated Kaposi’s sarcoma in Kenya: A qualitative study
(BMC, 2022)Background: Kaposi sarcoma is one of the most prevalent HIV‑associated malignancies in sub‑Saharan Africa and is often diagnosed at advanced stage of disease. Only 50% of KS patients who qualify for chemotherapy receive ... -
Viral load status before switching to dolutegravir-containing antiretroviral therapy and associations with Human Immunodeficiency Virus treatment outcomes in Sub-Saharan Africa
(Oxford University Press, 2021)Background. Dolutegravir is being rolled out globally as part of preferred antiretroviral therapy (ART) regimens, including among treatment-experienced patients. The role of viral load (VL) testing before switching patients ... -
Understanding diagnostic delays for kaposi sarcoma in Kenya: A qualitative study
(2022)Background: Although HIV-associated Kaposi sarcoma (KS) is frequently diagnosed at an advanced stage in sub-Saharan Africa, reasons for diagnostic delays have not been well described. Methods: We enrolled patients >18 years ... -
Postpartum care in Uganda: facility readiness, midwives perspectives, individualized care planning and patient outcomes
(Makerere university, 2025)Background: Globally, a woman dies every two minutes due to pregnancy or childbirth. Two-thirds of maternal deaths occur in the postpartum period and in Sub-Saharan Africa due to preventable causes such as sepsis, postpartum ...
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