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Molecular Diversity of HIV-1 among Long Term Non-progressors attending MJAP-ISS clinic, Mulago
(Makerere University, 2018-11)
Background: To date efforts are still being made to develop an efficacious and safe vaccine to stop the spread of Human Immunodeficiency Virus. Long term non-progressors (LTNPs); who harbour the virus but clinically show ...
Knowledge, attitude and use of direction signs among patients and care givers within Mulago national referral hospital.
(Makerere University, 2018-05-07)
Background
Signage is a way of creating knowledge or awareness of where one is going prior to arrival. Signs are used in various environments such as large facilities, schools, roads etc. Before the existence of language, ...
Nasopharyngeal co-colonization and drug resistance patterns of potentially pathogenic bacteria in children attending Mulago assessment centre Pediatric Unit of Mulago National Referral Hospital, Uganda
(Makerere University, 2019-10)
Background: The human nasopharynx is colonized by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. These bacteria may cause several diseases, especially in young children. ...
Evaluation of levels of T. cruzi ribosomal P protein homologous antigens and IgG antibodies among patients with Endomyocardial Fibrosis in Mulago Uganda
(Makerere University, 2017-11-22)
Endomyocardial Fibrosis (EMF) is a chronic inflammatory disease of the heart whose cause is still unknown yet about 10 to 12 million people are affected worldwide. In Uganda EMF prevalence is about 10-20% of all the cardiac ...
The prevalence and factors associated with allergic rhinitis among asthma patients 3 to 18 years attending the chest clinics at Mulago Hospital
(Makerere University, 2015-08)
Introduction
Allergic rhinitis is the most common allergic respiratory disorder globally. It constitutes a public health problem with a prevalence of 10% - 40%. The trend is increasing, affecting 19% of the general ...
Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens
(2019-10)
Background
Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets. Despite this, cellular and humoral immune responses against schistosomula ...
DEVELOPMENT AND OPTIMIZATION OF AN IN VITRO METHOD TO FORCE AND SELECT FOR FUNCTIONAL HIV-1 INTERSUBTYPE pol RECOMBINANTS
(Makerere University, 2019-10-22)
Introduction
Inter subtype recombination in the pol gene of the HIV-1 affects the enzymatic structure and
integrity which greatly impacts their function. These may be silent, deleterious or beneficial for
the survival ...
CDd4 t- cell immune responses in haart-treated hiv-infected adults who attain normal CD4 counts in a Ugandan cohort
(Makerere University, 2014-05)
Background: Majority of HIV-infected individuals who start HAART at CD4 counts <200 cells/µl show a marked CD4+T-cell increase to absolute CD4 counts above 500 cells/µl. The CD4+ T-cell count is the main measure for immune ...
The microbiome in the blood of HAART-Naive HIV positive patients
(2018-11)
Introduction: Infection with HIV results in the loss of gut mucosal CD4 T cells of the Th17 subtype responsible for maintaining integrity of the mucosa well as antimicrobial immunity. This results in an upset in the balance ...
BRCA1 and BRCA2 mutations in selected exons in breast cancer patients attending Mulago Hospital, Uganda
(Makerere University, 2017-02)
Breast cancer 1 (BRCA1) and Breast cancer 2 (BRCA2), mutation recognition is crucial for cancer risk assessment, identification of suitable breast cancer treatments, and personalised breast cancer prophylaxis in mutation ...