School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 61-80 of 397
-
Mycobacterium tuberculosis associated immune activation, inhibition and exhaustion profiling to predict active tuberculosis disease among presumptive tuberculosis participants and monitor anti-tuberculosis treatment response.
(Makerere University, 2023)Globally, tuberculosis (TB) is the leading cause of mortality and morbidity especially among resource-limited populations including Uganda. This statistic is greatly fueled by the delay in diagnosis of the disease and ... -
Stakeholders’ knowledge, perspectives and willingness to donate solid organs and associated ethical concerns in Uganda: a case study of Kampala
(Makerere University, 2023-11)Background The demand for human organs globally is higher than the supply. The government has enacted The Uganda Human Organ Donation and Transplant Act, 2022 aimed at regulating organ donation and transplant activities. ... -
HLA Class I and Pediatric HIV disease progression in Botswana and Uganda
(Makerere University, 2023)Sub-Saharan Africa remains the global epicenter of the HIV epidemic; more than 70% (25 million) of all people living with HIV/AIDS are in Africa. To end the global epidemic, finding an effective HIV vaccine remains a top ... -
Genetic determinants of differential susceptibility to hepatitis B Infection among a general population cohort from southwestern Uganda: a genome-wide association study
(Makerere University, 2023-11)Introduction: Hepatitis B is one of the major causes of mortality and morbidity worldwide. Hepatitis B infection causes liver inflammation and damage that may progress to liver cirrhosis, liver cancer and ultimately lead ... -
Molecular identification of fungal species associted with Mycetoma in Uganda.
(Makerere University, 2023-12-12)Background: Designated by the World Health Organization (WHO) as a neglected tropical disease (NTD), mycetoma is a chronic subcutaneous fungal and bacterial disease which causes profound morbidity. Mycetoma is mostly not ... -
Employing whole genome sequencing to elucidate the pathogenic and Antimicrobial resistance potential of Klebsiella Oxytoca clinical isolates from Mulago Referral National Hospital in Uganda
(Makerere University, 2023-11-13)Introduction: Klebsiella oxytoca (K. oxytoca) comprises a complex of related Gram negative opportunistic bacterial pathogens with scantly explored emerging antimicrobial resistance globally. Evidence shows shared virulence ... -
Anatomical Variations of Gall bladder and Bile ducts-An MRI study
(Makerere University, 2023-11-04)Introduction: The Anatomy of the biliary tree is complex and is characterized by the frequent presence of Anatomical variations which can be found in ~50% of the general population. Accurate knowledge of the bile duct ... -
Describing the nasopharyngeal microbiota of covid-19 patients in Uganda using next generation metagenomic sequencing and machine learning approaches
(Makerere University, 2023-11)Background: While COVID-19 spread globally, the role of respiratory co-infections in patient outcomes and their prevalence has remained an area of exploration. Prior findings suggest a dominance of bacterial co-infections, ... -
Molecular epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae among males with urethritis in Kampala, Uganda
(Makerere University, 2023-09-21)Gonorrhoea is a highly prevalent bacterial sexually transmitted infection (STI) that negatively impacts sexual and reproductive health (SRH) and that is also greatly associated with serious clinical sequelae. Gonorrhoea ... -
In vitro efficacy of bacteriophages against Extended-spectrum β-Lactamase producing Escherichia coli Isolated from Patients with Urinary Tract Infections
(Makerere University, 2021-04)Background: Escherichia coli, a gram-negative bacterial pathogen, which harbors extended spectrum β-lactamase enzymes (ESBLs) is the major cause of UTIs. The wide spread emergence and expansion of ESBL producing E. coli ... -
Evaluation of antidepressant effects and safety of Lavendula angustifolia aqueous and total crude leaf extracts in Wistar albino rats.
(Makerere University, 2023-07-28)Introduction: Depression continues to be a major problem in Ugandan population and communities’ use medicinal plants like L. angustifolia (Lavandula angustifolia) for its treatment.Objective: To establish the antidepressant ... -
Evaluation of the Diagnostic Validity of the HIV VISITECT CD4 Point-of-Care Rapid Diagnostic Test Using PIMA Analyzer as the Gold Standard in Uganda.
(Makerere University, 2023-09-30)Background: HIV remains prevalent in Uganda, and the cluster of differentiation-4 (CD4) markers are widely used to support and monitor disease progression. Objectives: This study aimed to compare the diagnostic validity ... -
Mutations in MDR-TB Isolates from Bedaquiline-Resistance Conferring Mulago Hospital Kampala, Uganda
(Makerere University, 2023-11-20)Introduction: In 2018, based on an evidence-based policy, the World Health Organization (WHO) updated its guidelines on the treatment of drug-resistant tuberculosis with recommendation of bedaquiline as a core drug in the ... -
L everaging on the Cross-Reactivity and recovery of leptospira serovars in stored cultures to mitigate limitations of the Microscopic Agglutination Test
(Makerere University, 2023-11-13)Leptospirosis is one of the most widely spread bacterial zoonotic that is endemic in subtropical and tropical countries; accounting for a global annual incidence of 1.03 million human cases and 58,900 deaths. (Alinaitwe ... -
Genomic determinants of virulence and antimicrobial resistance in colistin resistant Klebsiella pneumoniae isolates from Mulago National Referral Hospital
(Makerere University, 2023-08-29)Introduction: Multidrug resistance and high virulence in K. pneumoniae are of particular concern and have emerged as critically alarming threats to the global community. Worringly, K.pneumoniae has become resistant to ... -
Evaluation of the ameliorative effects of the methanolic and total crude extracts of Persea americana seeds on biochemical and haematological parameters in wistar albino rats induced with type 2 diabetes mellitus.
(Makerere University, 2023-11)Diabetes Mellitus is a chronic hyperglycaemic condition caused by low insulin production with 2 major types i.e., Type 1 and Type 2 DM (NIDDM). Type 2 DM accounts for 90% of DM cases and its global prevalence is expected ... -
Identification of loci associated with environmental adaptation in indigenous cattle of Uganda
(Makerere University, 2023-11)Cattle are invaluable to the people of Uganda. They are a source of pride of tribes and are also used in social functions. In Uganda, local breeds of cattle are kept due to their tolerance to locally prevailing animal pests ... -
Occurrence of extended Spectrum Beta-Lactamase producing Enterobacteriaceae in wastewater and receiving water bodies.
(Makerere University, 2023)Antimicrobial resistance is taking center-stage in increasing morbidity and mortality, especially in Low- and middle-income countries like Uganda. WHO drew a roadmap to increase antimicrobial resistance surveillance using ... -
The HBV Serological patterns, Treatment eligibility, Genotypes and the TNF-α-863C/A & 1031 T/C Promoter gene polymorphisms in a high and low endemic region of Uganda.
(Makerere University, 2023-04-14)ABSTRACT Introduction: There is a disparity in HBV endemicity in Uganda. This can be influenced by the HBsAg seronegative persons who continue to shade the virus, chronically infected HBV not initiated on therapy, the ... -
Effects of Helminth Infections on Type-2 Immune Responses in children with asthma
(Makerere University, 2023-11-14)Background: Both asthma and helminths demonstrate a predominant type-2 immune response. Additionally, helminths have been demonstrated to have immuno-modulatory roles in allergic conditions such as asthma. Therefore, the ...