School of Bio-Medical Sciences (Bio-Medical): Recent submissions
Now showing items 81-100 of 397
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African human variants that potentially impact the outcome of SARS-CoV-2 infection
(Makerere University, 2023-11-15)Introduction: The SARS-CoV-2 pandemic has had an unprecedented global impact, resulting in millions of confirmed cases and deaths. However, the severity and death rates varied among different ethnicities and geographical ... -
Diagnostic accuracy of mycobacterium tuberculosis DNA as detected by the top assay among the individuals with paucibillary TB
(Makerere University, 2023-11)Background: One of the major reasons leading to the increased incidence of TB is the lack of a diagnostic with high sensitivity that can be relied on to capture even patients with low burden TB. This had been attempted by ... -
Immunological Biomarkers among patients with Severe COVID-19
(Makerere University, 2023-11)Background: SARS-COV 2 is characterized by a heterogenous disease course in which some cases may be asymptomatic, mild, and severe which is life-threatening. Most hospitalized patients with COVID-19 have been found to have ... -
Bacterial profile and antimicrobial susceptibility patterns of isolates from surgical site infections at Luwero hospital
(Makerere University, 2023-11-14)Background: A surgical site infection (SSI) is an infection that develops within at most 30 days following a surgical procedure or after one year in case if an implant was placed. The American Centers for Disease Control ... -
Bacterial-Derived Outer Membrane Vesicles in Chronic Obstructive Pulmonary Disease and HIV Infection in a Ugandan Population
(Makerere University, 2023-11-01)Background: The prevalence of chronic obstructive pulmonary disease (COPD) has increased among people living with HIV (PLWH) despite the global scale-up of antiretroviral therapy (ART). Currently, it is not fully known ... -
Diagnostic performance evaluation of lateral flow florescence immunoassay (LFIA)- based point-of-care platforms in the measurement of selected cancer makers; PSA, CEA and CA125
(Makerere University, 2023-11-14)Background: In Uganda, cancer diagnosis has been largely dependent on conventional methods such as histopathology. These methods although very accurate they however require specialized facilities with trained personnel ... -
Human Cytomegalovirus infection in febrile patients with hematological malignancies at Uganda Cancer Institute
(2017-11-14)Background: Sub-Saharan Africa is experiencing a marked increase in the burden of cancer-related morbidity and mortality, with more than 1 million incident cancers and nearly 800 000 cancer-related deaths projected annually ... -
Characterizing microbial diversity and resistome in urban sewage using shotgun metagenomics in Kampala, Uganda
(Makerere University, 2023-05)Introduction: Recently, antimicrobial resistant (AMR) infections have shown up as the leading threat to human health, having 700,000 directly attributed estimated deaths per year worldwide. For Africa, AMR data is still ... -
Genomic study of Klebsiella pnuemoniae from neonatal invasive, neonatal and maternal carriage at Kawempe National Referral Hospital, Uganda
(Makerere University, 2023-11-14)Neonatal infections particularly bloodstream infections (BSI) pose a significant health risk, necessitating a comprehensive understanding of the genetic characteristics of causative strains for effective treatment and ... -
Bacille calmette-guérin, diphtheria-tetanus, and measles vaccine responses of infants born to mothers with active tuberculosis disease
(Makerere University, 2023-11-14)Background: Babies born to mothers with active tuberculosis disease (ATB) are at risk of poor clinical outcomes such as low birth weight and perinatal mortality. However, little is known about the influence of maternal ... -
Prevalence of protective levels of anti-HBs antibodies among 15-17 year old adolescents at kawempe division,Kampala,Uganda
(Makerere University, 2023-11-04)BACKGROUND: Viral hepatitis is a global pandemic and HBV is one of the leading causes of liver-related cancer and cirrhosis. The inclusion of the HBV vaccine in National Immunization programs has contributed to the reduction ... -
Moral distress and coping strategies among nurses and midwives at Kawempe National Referral Hospital Kampala District
(Makerere University, 2023-07-28)Background: Moral distress is a major issue in nursing practice, especially for those in clinical care. The existence of such distress may affect nurses’ physical and mental health, as well as their quality of life and ... -
Binding characteristics of selected commercial antibodies against recombinant HIV Subtype D P24 antigens
(Makerere University, 2023-01)The standard method for monitoring HIV treatment response is quantitative RT-PCR, but it is difficult to implement in low and middle income countries due to infrastructure and personnel requirements. Point of care technologies ... -
Characterisation of Candida africana among pregnant women with vaginitis
(Makerere University, 2023-11)Candida africana, an emerging variant within the Candida albicans complex, has a global intra-albicans complex prevalence of 1.67% and varies between 0% and 8.4% depending on the region. It mainly causes vulvovaginal ... -
Inflammaging and anti-inflammaging cytokines in the HIV-seropositive geriatric population in Uganda
(Makerere University, 2023)Background: Although the life expectancy of people living with HIV (PLWH) has increased significantly, HIV infection seems to be associated with accelerated ageing processes compared to uninfected individuals. Longevity ... -
Immunological and genetic risk factors associated with cognitive and neurological impairment in severe malaria in Ugandan children
(Makerere University, 2023)Background. Endothelial activation is involved in pathophysiology of severe malaria leading to blood-brain-barrier dysfunction (BBB), which could occur in the absence of neurologic signs, or may be associated with long-term ... -
Performance evaluation of computational programs to predict Human leucocyte antigen (HLA) genotypes on African whole exome sequence data
(Makerere University, 2023)Introduction: Accurate Human Leucocyte Antigen (HLA) genotyping is critical in studies involving the immune system and transplantation medicine. HLA genes encode proteins that have a central role in immune responses that ... -
Perceptions and experiences on identification and management of conflicts of interest during the ethical review process.
(Makerere University, 2022-04)Background: The increasing growth of research involving humans in Uganda has been paralleled with the establishment of research ethics committees. These committees conduct ethical review of research protocols to ensure ... -
Comparative assessment of regulatory T and B cell phenotype frequencies in active, latent and Tuberculosis negative individuals
(Makerere University, 2023-01-01)Background: Literature shows that regulatory B cells (Bregs) and regulatory T cells (Tregs) play a part in the control of many inflammatory diseases including tuberculosis (TB) by regulating the CD4 Tcell responses. This ... -
An evaluation of the microbiological quality of commonly marketed dietary supplements in retail pharmacies in Kampala City, Uganda
(Makerere University, 2023)Background: Dietary supplements are products that contain concentrated sources of nutrients and whose purpose is to add nutritional value (supplement) to normal diet. One of the critical indicators of the safety of dietary ...