Infectious Diseases Institute (IDI) Collections: Recent submissions
Now showing items 61-80 of 119
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Low prevalence of pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia
(SciVerse ScienceDirect, 2012-02-15)Pneumocystis jirovecii is an important opportunistic infection in human immunodeficiency virus (HIV)–infected patients. In the developed world, P. jirovecii epidemiology is marked by frequent colonization in immunosuppressed ... -
Artemether-Lumefantrine combination therapy for treatment of uncomplicated malaria: The potential for complex interactions with antiretroviral drugs in HIV-infected individuals
(Malaria Research and Treatment, 2011-02-14)Treatment of malaria in HIV-infected individuals receiving antiretroviral therapy (ART) poses significant challenges. Artemether-lumefantrine (AL) is one of the artemisisnin-based combination therapies recommended for ... -
Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
(Elsevier, 2008-08)The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there ... -
Palliative care in sub-Saharan Africa
(2005-08-13)We agree with Richard Harding and Irene Higginson (June 4, p 1971) and Anne Merriman and Manjit Kaur (p 1909) that improving palliative care services for people living with HIV/AIDS in sub-Saharan Africa is extremely ... -
Prevalence, incidence and predictors of severe anaemia with zidovudine-containing regimens in African adults with HIV infection within the DART trial
(International Medical Press, 2006)Objective: To describe the prevalence, incidence and predictors of severe anaemia in previously untreated symptomatic HIV-infected adults with CD4+ T-cells <200 cells/mm3 initiating zidovudine-containing regimens in Africa. ... -
Treatment of severe sepsis with Artemether-Lumefantrine Is associated with decreased mortality in Ugandan patients without malaria
(The American Society of Tropical Medicine and Hygiene, 2009)We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a post hoc analysis of the association ... -
The TB pandemic: an old problem seeking new solutions
(Blackwell, 2007)Meya DB, McAdam KPWJ (Infectious Disease Institute, Kampala, Uganda). The TB pandemic: an old problem seeking new solutions (Review). J Intern Med 2007; 261: 309–329. Tuberculosis (TB) continues to kill more than 2 million ... -
Successful Treatment of Psoriasis-like Lesions in HIV Infected Patients in Uganda with Chloroquine
(Open Infectious Diseases Journal, 2009)The effect of chloroquine in the treatment of psoriasis remains controversial.Treatment of psoriasis in HIV infection is not well described. Chloroquine has been shown to have direct effects on both the Human Immunodeficiency ... -
When to switch for antiretroviral treatment failure in resource-limited settings?
(Lippincott Williams & Wilkins., 2007)Thanks to the leadership of the World Health Organisation (WHO) [1], and massive financial support from programmes such as the Global Fund and the US President’s Emergency Plan for AIDS Relief (PEPFAR), the number of ... -
Update on the efficacy, effectiveness and safety of artemether–lumefantrine combination therapy for treatment of uncomplicated malaria
(Dove Medical Press, 2009)Artemether–lumefantrine is one of the artemisisnin-based combination therapies recommended for treatment of uncomplicated falciparum malaria. The drug combination is highly efficacious against sensitive and multidrug ... -
Rolling out antiretrovirals in Africa: there are still challenges ahead
(Infectious Diseases Society of America, 2005-08)In their article “Lessons Learned from Highly Active Antiretroviral Therapy in Africa,” Akileswaran et al. [1] review the effectiveness of HAART programs in Africa. They report positive health outcomes, including high ... -
Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a Resource-Limited Setting (Uganda).
(University of Chicago Press, 2007)We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. All patients were receiving combination therapy that ... -
Resurrecting the triple threat: academic social responsibility in the context of global health research
(CID, 2009-05-15)As a result of the pandemic of human immunodeficiency virus infection, more academic physicians involved in research are working in resource-limited settings, especially in the field of infectious diseases. These researchers ... -
Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care
(BioMed Central, 2011)Background: Observational HIV clinic databases are now widely used to answer key questions related to HIV care and treatment, but there has been no systematic evaluation of their quality of data. Our objective was to ... -
Potential impact of task-shifting on costs of antiretroviral therapy and physician supply in Uganda
(BMC Health Services Research, 2009-01-09)Background Lower-income countries face severe health worker shortages. Recent evidence suggests that this problem can be mitigated by task-shifting—delegation of aspects of health care to less specialized health workers. ... -
Sexual risk reduction needs of adolescents living with HIV in a clinical care setting
(Taylor & Francis (Routledge), 2008-04)As anti-retroviral therapy becomes increasingly available, young people living with HIV need tailored support to adopt healthy sexual behaviors. There has been a gap in the availability of culturally appropriate techniques ... -
Point-of-care lactate testing predicts mortality of severe sepsis in a predominantly HIV type 1–infected patient population in Uganda
(Infectious Diseases Society of America, 2008)Background: Prediction of mortality may improve management and outcomes of patients with sepsis in resource-limited settings. Therefore, we evaluated the ability of a hand-held portable whole-blood lactate (PWBL) analyzer ... -
Pattern of neuropsychological performance among HIV positive patients in Uganda
(BioMed Central, 2007)Background: Few studies have examined cognitive functioning of HIV positive patients in sub-Saharan Africa. It cannot be assumed that HIV positive patients in Africa exhibit the same declines as patients in high-resource ... -
Nucleic acid amplification tests for diagnosis of smear-negative TB in a high HIV prevalence setting: a prospective cohort study
(Public Library of Science, 2011-01)Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. ... -
Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy
(CID, 2008)Background. Cryptococcal meningitis (CM) is the proximate cause of death in 20%–30% of persons with acquired immunodeficiency syndrome in Africa. Methods. Two prospective, observational cohorts enrolled human immunodeficiency ...